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Natural Killer cell control of BRAFV600E mutant melanoma during targeted therapy

Identifieur interne : 002A99 ( Main/Exploration ); précédent : 002A98; suivant : 002B00

Natural Killer cell control of BRAFV600E mutant melanoma during targeted therapy

Auteurs : Lucas Ferrari De Andrade [Australie, États-Unis] ; Shin Foong Ngiow [Australie] ; Ludovic Martinet [Australie, France] ; Mark J. Smyth [Australie]

Source :

RBID : PMC:4485837

Abstract

Pharmacologic inhibition of the mutant BRAFV600E protein in advanced BRAFV600E melanoma results in a high proportion of patients that respond, but few with durable responses. We have recently revealed that Natural Killer (NK) cells play an essential role in the BRAFV600E inhibitor control of melanoma metastases in mice that may be therapeutically exploited to help overcome drug resistance.


Url:
DOI: 10.1080/2162402X.2014.998119
PubMed: 26137412
PubMed Central: 4485837


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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<sup>V600E</sup>
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<sup>V600E</sup>
</italic>
inhibitor control of melanoma metastases in mice that may be therapeutically exploited to help overcome drug resistance.</p>
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