Natural Killer cell control of BRAFV600E mutant melanoma during targeted therapy
Identifieur interne : 002A99 ( Main/Exploration ); précédent : 002A98; suivant : 002B00Natural Killer cell control of BRAFV600E mutant melanoma during targeted therapy
Auteurs : Lucas Ferrari De Andrade [Australie, États-Unis] ; Shin Foong Ngiow [Australie] ; Ludovic Martinet [Australie, France] ; Mark J. Smyth [Australie]Source :
- Oncoimmunology [ 2162-4011 ] ; 2015.
Abstract
Pharmacologic inhibition of the mutant BRAFV600E protein in advanced BRAFV600E melanoma results in a high proportion of patients that respond, but few with durable responses. We have recently revealed that Natural Killer (NK) cells play an essential role in the
Url:
DOI: 10.1080/2162402X.2014.998119
PubMed: 26137412
PubMed Central: 4485837
Affiliations:
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Le document en format XML
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; Toulouse,<country>France</country>
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<front><div type="abstract" xml:lang="en"><p>Pharmacologic inhibition of the mutant BRAF<sup>V600E</sup>
protein in advanced BRAF<sup>V600E</sup>
melanoma results in a high proportion of patients that respond, but few with durable responses. We have recently revealed that Natural Killer (NK) cells play an essential role in the <italic>BRAF<sup>V600E</sup>
</italic>
inhibitor control of melanoma metastases in mice that may be therapeutically exploited to help overcome drug resistance.</p>
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